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Over time, this can lead to a variety of health problems, including weight gain, high blood pressure, and an increased risk of type 2 diabetes

The adaptation might have occurred earlier, then receded by the time measurements were taken

Interestingly, biopsies from asthma patients support this observation, with reduced levels of RAMP1 compared to the controls ( Calcitonin-gene related peptide modulates the Th9 response (response related to TIHS), inducing the expression of GATA3 and PU.1 (transcription factor of Th9 cells) and IL-9 production, enhancing airway inflammation (Mikami et al., 2013)

Prostaglandins 18: 179-190

This indicates that differences between species may influence outcomes, despite using the same concentration range