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Semaglutide was originally used to treat Type 2 diabetes by regulating blood sugar levels

GLP-1s for Chronic Kidney Disease GLP-1s for Advanced Liver Disease In August 2025, the FDA approved Wegovy (semaglutide) to treat adults with a type of liver disease called metabolic-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), when used alongside diet and exercise

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Several clinical trials have compared the effects of Semaglutide and Tirzepatide, particularly in people with type 2 diabetes