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These translational findings are an outgrowth of a mechanistic model in rodents with impaired plasticity of key brain areas relevant to mood, cognitive and other main disorders, wherein LAC levels are markedly decreased and signal abnormal brain and systemic functions

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Sean Wharton The first coprimary endpoint of mean change in body weight at 72 weeks was 18.7% in the semaglutide 7.2 mg group, 15.6% in the semaglutide 2.4 mg group and 3.9% in the placebo group (estimated treatment difference between semaglutide 7.2 mg and semaglutide 2.4 mg, 3.1 percentage points