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As a powerful Nrf2 agonist found in cruciferous vegetables (130), Nrf2 activation induced by sulforaphane treatment not only upregulates its downstream target genes, including xCT, GPX4 and multiple Atgs, but also disrupts the formation of Beclin1-xCT complex by promoting autophagy

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doi: 10.3109/15563650.2014.946994 [PubMed] 25767408 Mahmoudi GA, Astaraki P, Mohtashami AZ, Ahadi M