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The translation pipeline (Figure 3) typically progresses from identifying a promising metabolite or herbal formula, demonstrating efficacy in cellular and animal models, ensuring quality control in formulation, conducting early-phase human safety studies, then larger efficacy trials, and finally seeking guideline inclusion if successful

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High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells