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TfR1 recycles to the cell surface during this process for continued iron transport

This study population was then divided into two cohorts: (1) Semaglutide cohort 688 patients prescribed semaglutide, and (2) non-GLP1-RA anti-obesity medication cohort 1,346 patients prescribed non-GLP-1RA anti-obesity medications but not semaglutide

Studies have shown (13) that GLP-1R is expressed in normal pancreatic islet, acinar and duct cells, and Waser (83) reported that GLP-1R is highly expressed in normal pancreatic secretory cells, expressed at low level in pancreatic acinar cells, not expressed in pancreatic duct cells, and expressed at low or no levels in human pancreatic cancer tissues

Mutations in the NHF4A gene are the cause of MODY1

This mechanism will be further explained later in this manuscript