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Studies with NR supplementation in PD or HF patients have provided indications of impacting mitochondrial function in peripheral tissues, although evidence for impacting mitochondria in the primary target tissues was not reported 318,319

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doi: 10.1016/j.psychres.2020.112757 19 GawrylukJWWangJFAndreazzaACShaoLYoungLT

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Collagen-producing fibroblasts depend on adequate vascular supply to sustain their metabolic demand during active matrix synthesis, making angiogenesis a prerequisite for effective structural repair