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An imbalance in the ratio between reduced (GSH) and oxidised (GSSG) forms of glutathione is implicated in various enterovirus infections 23 and depletion of cellular GSH levels using the GSH biosynthesis inhibitor L-buthionine sulfoximine (BSO) 24,25 and the small molecule inhibitor TP219 26 blocks the assembly and morphogenesis of many enterovirus capsids

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In animals, SNX1 and SNX2 are homologous to Vps5p, whereas SNX5 and SNX6 share a common ancestor with Vps17p and are closely related