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Safety and immunogenicity of ChAdOx1 MERS vaccine candidate in healthy Middle Eastern adults (MERS002): an open-label, non-randomised, dose-escalation, phase 1b trial

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Retatrutide Retatrutide represents another approach to multi-pathway activation, functioning as a triple agonist (GIP/GLP-1/glucagon) in a single molecule: Cagrilintide + GLP-1 Approach: Two separate injections Amylin + GLP-1 pathways Established safety profile for each component Flexible dose adjustment of each component Retatrutide Approach: Single injection GIP + GLP-1 + Glucagon pathways Novel triple mechanism in one molecule Fixed ratio of pathway activation Both approaches show promise for significant metabolic benefits, though they achieve multi-pathway activation through different strategies

152 RamakrishnaC.KujawskiM.ChuH.LiL.MazmanianS