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Despite robust clinical evidence, barriers such as high costs, limited access, lack of awareness of approved indications, and practitioner hesitancy continue to impede widespread adoption

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The encouraging news is that many strategies reduce or remove the odor ranging from simple pauses in supplementation to targeted clinical approaches in confirmed cases

**Tretinoin:** Best for treating acne and deep wrinkles, but may require careful introduction to avoid irritation

Its safety profile in early human trials appears good, though long-term data are limited