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With regard to PD pathophysiology, the selective neuronal death in substantia nigra pars compacta constitutes a landmark finding, followed by the description of the classical basal ganglia model comprising the direct, indirect and the more recently added, hyperdirect pathways that regulate the control of movement (Albin et al

Some of those, like insulin, are naturally occurring in the body

For semaglutide specifically, no strong evidence indicates it should be stopped before a colonoscopy

Activity & rest: Pair appropriate movement with adequate rest and avoid overexertion

Semaglutide has also been associated with a very rare eye condition called non-arteritic anterior ischaemic optic neuropathy, or NAION