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The origin of using ln(2) as the proportionality constant can be shown by deriving the half-life from a differential equation for drug elimination
Woman with red urine: hydroxocobalamin-induced chromaturia
Local injections also carry a very small risk of introducing an infection into the joint but have the advantage that if gout has not as yet been definitively diagnosed a sample of fluid can be obtained using the same needle and analyzed for the presence of uric acid crystals
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