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10.1007/BF02172145 45

[52] While elders are more sensitive to GH, and thus more susceptible to the side effects of replacement with rhGH, stimulating production and secretion of endogenous GH with Sermorelin offers the advantage of a more physiological approach to increasing GH pulsatility while reducing risk for side effects

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46 The metabolism of islet beta-cells is designed to be sensitive to blood glucose levels as the hexokinase isozyme found in these cells is glucokinase which has a reduced affinity for substrate, resulting in glucose catabolism occurring when glucose concentration in the blood is 5mM or higher