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Mouse Tumour Studies Some mouse experiments reported lower frequencies of particular spontaneous tumours, fewer malignant tumours or altered metastasis outcomes

Thus, disruption of mitochondrial iron homeostasis may amplify oxidative injury to mitochondrial proteins, lipids, and DNA, compromise ATP generation, and ultimately trigger energy stress that converges on ferroptotic cell death

Samples were processed with the One-Cycle Target Labeling and Control Reagents Kit (Affymetrix, Santa Clara, CA, USA) and hybridized on HG-U133 Plus 2.0 Arrays (Affymetrix)

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