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The primary limitation relates to the modest sample size and short intervention duration, which may limit precision and long-term inference but does not substantially undermine internal validity under JBI criteria

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The peptide complex restores extracellular matrix homeostasis by increasing the synthesis and turnover of collagen, elastin, and glycosaminoglycans, as well as by modulating the balance between metalloproteinases (MMPs) and their inhibitors (TIMPs), thus supporting both matrix remodeling and scar resolution 2,3

Additional work by Khorram et al