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While tirzepatide has modest effects on metabolism , retatrutide appears to meaningfully elevate resting metabolic rate through this glucagon-mediated pathway

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The SURPASS-CVOT (Cardiovascular Outcomes Trial) was designed specifically to assess major adverse cardiovascular events, comparing tirzepatide to dulaglutide (not placebo)

Switching from Wegovy Pill to the Injection If you are switching from the Wegovy pill to the injection, you can usually start the injection the day after taking your last pill dose