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Steady-state exposure is achieved following 4-5 weeks of once-weekly administration

Many researchers who transition from tirzepatide to retatrutide find the side effect timing quite similar since both medications share the GIP pathway

Side Effect Comparison *Estimated from available trial data

doi: 10.1080/21688370.2016.1176822 Summary Keywords glucagon-like peptide-1 receptor agonist (GLP-1RA), oral, subcutaneous, semaglutide, type 2 diabetes, safety Citation Smits MM and Van Raalte DH (2021) Safety of Semaglutide

Medication Interactions Semaglutide may interact with other medications, further increasing the risk of anemia