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Additional caution should be taken when prescribing these medications to populations excluded from clinical trials, she added

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Changes in adipokines and associated inflammation in adipose tissue during aging Adipocytes secrete various adipokines, which profoundly affect appetite and satiety, adipogenesis, inflammation, and other physiologic functions [103]

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A structured checklist and timeframesuch as contacting a clinician after 12 weeks of persistent moderate nausea despite conservative measuresaligns patient expectations with clinical practice

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