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Arch Immunol Ther Exp (1996) 44:516
Devices to overcome the buccal mucosal barrier to administer therapeutic peptides
On phase: up to 3 months of active dosing, following the Month 1 to Month 3 titration
Allowing endogenous myrosinase to act increases conversion of glucosinolates to isothiocyanates
As used herein, practical osmolarity means the osmolarity of a formulation that is measured by including the active agent and all excipients except the gelling and/or the thickening agent (e.g., polyoxyethylene-polyoxypropylene copolymers, carboxymethylcellulose or the like)
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