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Future investigations should focus on understanding the role of NLRP3 at different phases of APAP-induced liver injury, its activation in various cell types, including hepatocytes and Kupffer cells, and validating its involvement in liver damage in multiple animal models through comparative analyses

Pharmacological activation of NRF2: BACH1 inhibitors BACH1 antagonizes NRF2 at the DNA binding site of antioxidant genes and thereby represses the expression of NRF2s target genes