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Robinson-Cohen et al., 2016)

In PD, the substantia nigra exhibits markedly elevated free iron concentrations alongside reduced iron-storing neuromelanin, leading to increased cytoplasmic iron release (Shamoto-Nagai et al., 2006)

With portfolio value consolidating into these fewer, larger assets and the cost to develop them continuing to climb there is a precarious balance of high potential returns and the risk of significant value destruction from a single program failure