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Lactulose, rifaximin or branched chain amino acids for hepatic encephalopathy: What is the evidence

This process ultimately leads to cell death, activation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), and swelling of the cell (216, 226)

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Meanwhile, AA is oxidized to 5-HpETE, 12-HpETE, and 15-HpETE by 5-LOX, 12-lipoxygenase (12-LOX), and 15-lipoxygenase (15-LOX), respectively