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Additional observed toxic mechanisms included loss of MMP, upregulation of the proapoptotic protein Bcl-2-associated X protein (BAX), and downregulation of antiapoptotic markers such as B-cell lymphoma 2 (Bcl-2), poly ADP ribose polymerase (PARP), and caspase-3 [134]

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Other Ingredients: rice flour, gelatin (capsule), magnesium stearate (vegetable source), and silicon dioxide

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice