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In addition, it is one of the major conserved pathways of aging that regulate lifespan in model organisms across a great evolutionary distance from Caenorhabditis elegans (Kimura et al., 1997), Drosophila (Tatar et al., 2001), and to mice

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Other botanicals like bitter melon may be useful but are less standardized across preparations

406 FGF21 is recognized as a stress response factor that addresses mitochondrial dysfunction in cells