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Keywords: fibrosis, GLP1, incretin, MASH, MASLD Abbreviations ACC acetylCoA carboxylase ALT alanine aminotransferases AMPK AMPactivated protein kinase ChREBP carbohydrateresponse elementbinding protein ECM extracellular matrix ELF enhanced liver fibrosis panel FAS fatty acid synthase FAST FibroscanAST score GLP1 glucagon like peptide1 GLP1R glucagonlike peptide1 receptor GLP1RA glucagon like peptide1 receptor agonist HMGCR 3hydroxy3methylglutarylCoA reductase HSC hepatic stellate cells IL6 interleukin6 LSM liver stiffness measurement LTA4 leukotriene A4 MACE major adverse cardiovascular events MASH metabolic dysfunctionassociated steatohepatitis MASLD metabolic dysfunctionassociated steatotic liver disease MCP1 monocyte chemoattractant protein1 SCD1 stearoylCoA desaturase1 SREBP1c sterol regulatory elementbinding protein 1c T2D type 2 diabetes TNF tumour necrosis factor VCTE vibrationcontrolled transient elastography SMA smooth muscle actin Summary

However, treatment with lithium offers multiple benefits in BD apart from protection against relapses

#465489/2014-1) and the National Council for Scientific and Technological Development (CNPq

The tripeptide modulates over 4,000 human genes (31.2% of the genome) and plasma levels decline from approximately 200 ng/mL at age 20 to less than half by age 60 (Pickart & Margolina, 2018)