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Circulating tumor DNA (ctDNA) comprises the tumor-derived DNA fragment released into the bloodstream, depicting the real-time tumor burden and molecular alterations (193)

Additionally, elevated levels of homocysteine, hypoxia, and inflammation have the potential to alter the epigenetic control of genes in CKD (76, 80, 81)

Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR et al

No acute adverse events were reported in animal models within six weeks of administration