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321 Genetic ablation of GIPR in leptin-deficient obese ( ob/ob ) mice was shown to ameliorate insulin insensitivity and obesity by increasing energy expenditure without significantly affecting insulin secretion

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Cholecystokinin (CCK, 300 nM) was routinely applied to demonstrate the presence of vagal afferent fibres in the nerve bundles recorded, as previous studies by Richards et al

53 Finally, tirzepatide is a GLP1R/GIPR dual agonist, currently being evaluated in phase 3 trials

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