The mechanism is direct: both compounds amplify the body's natural nocturnal growth hormone pulse, which is physiologically coupled with slow-wave sleep
10.1111/pcn.12779 [DOI] [PubMed] [Google Scholar] 73.Bruno A, Pandolfo G, Crucitti M, Lorusso S, Zoccali R, Muscatello M
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OHearn, A
In contrast to co-treatment with GLP-1GIP plus Lani, the GLP-1GIPLani conjugate also fully prevented body weight gain in obesity-prone leptin receptor-deficient db/db mice (Extended Data Fig