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Headache, which occurred in all groups, was the most frequently reported AE following multiple-dose administration of the GDF8 + ActA mAb combination in postmenopausal females (Table 5)

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no confirmed human causation

The authors identified future areas of investigation including male models, long-term treatment effects, and combination with other NAD+ precursors such as NMN

Compared with untreated controls, microsomal protein concentrations were increased after twenty-eight days of treatment in C57BL mice, after four and twenty-eight days of treatment in C3H mice, after four days of treatment in B6C3F1 mice, and with no effect of treatment in C3B6F1 mice