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As usual, the story is incomplete

In contrast with adaptive memory, which lies on the gene recombination of antigen receptors and proliferation of specific lymphocyte clones, TI is triggered by the interplay between pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) and pattern recognition receptors (PRRs) on the innate immune cells, followed by long-term metabolic and epigenetic changes (99, 100) ( Figures 2 , 3 )

10.1016/j.abb.2003.09.007 Arch

Deng P, Chen Y, Ji N, Lin Y, Yuan Q, Ye L, et al