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During the trial, additional anti-diabetic medication was initiated as an add on to randomized treatment by 2.4%, 1.1% and 2.8% of patients randomized to RYBELSUS 7 mg, RYBELSUS 14 mg and sitagliptin 100 mg, respectively

Bromelain, another ingredient, may increase bleeding risk if you take blood thinners or antiplatelet drugs

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However, it should be noted, the genomic neighborhood for Glp1r in some rodents, including mouse ( Mus musculus ), has experienced a chromosomal translocation that might influence the regulation of this gene