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This perception persisted despite extensive evidence that endogenous peptides regulate virtually every major physiological system, including metabolism, cardiovascular homeostasis, neuroendocrine signaling, immune modulation, and tissue repair

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CMAJ 193(16):E561 Buchner A, Hansen LS (1979) Melanotic macule of the oral mucosa

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Non-oral contraception or backup methods are advised for 4 weeks after initiation and after each dose escalation