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Moreover, current therapies can cause severe long-term side effects and new therapies are urgently needed

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The advent of omics technologies has enabled researchers to explore tinnitus in greater detail using these advanced techniques 17,18

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Studies in Pink1 -deficient Drosophila and mouse models demonstrated that an early consequence of Pink1 deficiency is the disruption of complex I function, leading to mitochondrial membrane depolarization, increased sensitivity to apoptotic stress, and synaptic transmission deficits [90]