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*Correspondence: Wu Yang, [email protected] Xie, [email protected] This article was submitted to Molecular Signalling and Pathways, a section of the journal Frontiers in Molecular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

If nausea persists beyond 46 weeks or significantly impairs quality of life, dose reduction or alternative therapy should be considered