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Once the tetrapeptide Ac-His-Phe-Arg-Trp-NH 2 was identified as a message sequence of melanotropin, responsible for minimal physiological action in the frog [10] and lizard [11], a wide range of analogs was synthesized by the group of V

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Results are reported as adjusted odds ratios

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The aromatic rings of some of the hits also formed cation- interactions with positively charged groups of R144 and R181 (Figure S1)