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In rare, carefully controlled situations when a patient is facing otherwise life-threatening inflammatory disease the clinician and patient may decide the risk is worth it

Clin Pharmacol Ther 111(1):272282 Ueda P, Wintzell V, Melbye M, Eliasson B, Sderling J, Gudbjrnsdottir S, Pasternak B (2023) Use of DPP4 inhibitors and GLP-1 receptor agonists and risk of intestinal obstruction: Scandinavian cohort study

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First, there is a lack of standardized exercise protocols across studies, with wide variability in training type, frequency, intensity, and supervision, which limits comparability and prevents the identification of optimal regimens for preserving lean mass or enhancing metabolic outcomes