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Despus de su descubrimiento en extractos musculares en 1905 y su identificacin estructural en 1927, la importancia de la L-carnitina en la oxidacin de cidos grasos en el hgado y el corazn fue descrita por primera vez por Fritz en 1959

Any water with a pH lower than 7.0 is said to be acidic and water above 7.0 is called basic, as shown in the pH scale below

Acknowledgments We are thankful for the comments of the anonymous reviewers, which have significantly improved the quality and clarity of our manuscript

Based on a receptor-interaction model, structural modifications of the benzene and pyridine rings led to the identification of compound 26 (Figure 5), which includes a 2,4-dichlorophenyl group at two positions, as a potent (IC 50 = 0.13 M), selective (DPP-8/DPP-4 = 215, DPP-9/DPP-4 = 192), and in vivo efficacious DPP-4 inhibitor

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