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To keep patients safe, its important to check medical history, see if there are any drug interactions, and watch for any bad reactions closely

According to this mechanism, the threshold for initiating a neural response in the AWC sensory neurons is not fixed, but rather a dynamic variable that changes depending on the history of the perceived stimulus

doi: 10.3389/fphar.2025.1610793 Received 12 April 2025 Accepted 21 July 2025 Published 18 August 2025 Volume 16 - 2025 Edited by Michael Heinrich, University College London, United Kingdom Reviewed by Sena Ardicli, Bursa Uluda University, Trkiye Huiwen Pang, University of Queensland, Australia Updates Copyright 2025 Zedan, El-Moslemany, Bahnasy, Eldamaty, Ibraheim, Alotaibi, Abdelmegeid, Shukry and Elolimy

The Black Box warnings, full side effect list, and drug interaction details remain in the Safety Details section below