step-c) condensation of peptide resin obtained in step-b) with Fmoc-Ala-OFl in presence of a coupling agent
Its dual mechanism can sometimes yield better results for non-responders
PMD are genetic disorders that directly impair OXPHOS proteins or its function by impacting the complex machinery involved in the OXPHOS process
QALY = quality-adjusted life year, ICER = incremental cost-effectiveness ratio, GLP-1 RAs = glucagon-like peptide-1 receptor agonists, BMI = body mass index, WTP = willingness-to-pay, ESG = endoscopic sleeve gastroplasty, NHS = National Health Service, MBS = metabolic/bariatric surgery
doi: 10.3389/fped.2014.00066 Received 09 May 2014 Accepted 09 June 2014 Published 27 June 2014 Volume 2 - 2014 Edited by Roberto Canitano, University Hospital of Siena, Italy Reviewed by Andrew Walter Zimmerman, Harvard Medical School, USA