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As shown in that report, combination treatment with metformin and liraglutide can ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway 25

This structural modification also reduces its binding affinity to IGF binding proteins, allowing it to remain bioactive in circulation significantly longer than endogenous IGF-1

There is currently no official contraindication to using GLP-1 receptor agonists or GIP/GLP-1 receptor agonist weight loss injections concurrently with hormone replacement therapy

The studies also had some shortcomings, as some only administered fluoxetine at the end of pregnancy and could not assess the effects of the drug throughout the entire pregnancy period, some did not explore the specific mechanisms of fluoxetine-induced fetal acidosis, hypocalcemia, and altered maternal estradiol metabolism, and some failed to assess the maternal and fetal health status over a long-term follow-up period