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The evolving story of incretins (GIP and GLP-1) in metabolic and cardiovascular disease: a pathophysiological update

165 LRP6 is downregulated in the AD brain, and deficiency in LRP6-mediated Wnt/-catenin signalling contributes to synaptic dysfunction and amyloid pathology in AD

Supportive of this notion, a proof-of-concept study performed by Coopmans et al

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Within biochemical research environments, both peptides are frequently investigated for their interactions with intracellular signalling pathways and cytoskeletal regulatory systems