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Cells were treated with ferroptosis inducers including erastin (SelleckChem) and RSL3 (Sigma Aldrich), ferroptosis inhibitor ferrostatin-1 (Sigma Aldrich), -glutamylcysteine synthetase inhibitor L-Buthionine-(S,R)-sulfoximine, (BSO, Sigma Aldrich) and IRE1 inhibitors 48c (Sigma Aldrich) and MKC9989 (MedChemExpress)

There is also the matter of accountability

Opiorphin and kallikrein-kinin peptides are also noteworthy

From a translational perspective, prioritized next steps include well-designed pharmacokinetic and toxicology studies, reproducible efficacy assessments across models, and early-phase clinical trials that emphasize safety and tolerability