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Diabetes Care , 46 (Supplement 1), S1-S291

Patient 1 presented at birth with increased muscle tone in the peripheral muscles associated with pyramidal syndrome, and later experienced recurrent, intermittent clonic movements in the left lower extremity, which improved after intravenous phenobarbital administration

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However, peptide therapy remains an evolving field

Furthermore, Annexin V-FITC/PI double staining illustrated the mechanism of the cytotoxic properties of BV in T-47D and resistant cells through apoptosis, which was confirmed with increased expression of pro-apoptotic protein (BAX) and reduced levels of the anti-apoptotic (Bcl-2) protein, as shown immunohistochemically in vivo