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Current therapies often fail to fully address these cellular alterations in smokers, highlighting a need for innovative therapeutic and regenerative approaches

The ADA/European Association for the Study of Diabetes (EASD) 2019 consensus report recommended that the decision to use a GLP-1 RA or SGLT2i to treat individuals with high risk of major adverse CV events, hospitalisation for heart failure, CV death or chronic kidney disease should be independent of baseline HbA 1c or individual HbA 1c target [65]