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Somatic mutation of the NRF2 pathway genes plays a role in some human cancers (235, 236)

N Engl J Med 381(7):637646 Pfeffer MA, Claggett B, Diaz R, Dickstein K, Gerstein HC, Kber LV et al (2015) Lixisenatide in patients with type 2 diabetes and acute coronary syndrome

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it has also been implicated in the etiology of psychiatric disease

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