The expressions of HDAC5 and G protein-coupled receptor kinase 5 (GRK5) are upregulated in UUO-induced renal fibrosis mice model and HK-2 cells treated with TGF-

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Further studies also suggest that the amino-acid sequence of GHK-Cu may have an antioxidative potential on ROS, such as hydroxyl radicals, and it may be even stronger than generic antioxidative peptides
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