Research presented at the 2025 American Academy of Orthopaedic Surgeons meeting found GLP-1 users had approximately 30% higher rates of osteoporosis compared to non-users, and a 2024 phase 2 trial published in eClinicalMedicine showed increased bone resorption markers and lower bone mass at the spine and hip in the semaglutide group versus placebo after 52 weeks
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Post-hoc comparisons showed that the Firmicutes phylums relative abundance was significantly higher in WD control mice compared to mice in the vehicle- and 5A-1MQ-treated groups switched from WD to LD (Fig
For anxiety with chronic disease (ACD), the removal of one article (Mojtahedi et al., 2024) resulted in a substantial reduction in heterogeneity, with the I 2 value decreasing from 84% to 0%, while the treatment effect remained statistically significant, changing from SMD -0.32 (95% CI: 0.50, 0.15) to SMD -0.22 (95% CI: 0.40, 0.05)
Avoid acidic buffers or low-pH solutions which may destabilise the copper complex
