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Results at 68 weeks: 40.4% of CagriSema participants lost 25% or more of their body weight 91.9% lost at least 5% Blood pressure fell by 10.9 mmHg systolic on average About 40% of participants reduced or stopped blood pressure medications 87.7% of those with prediabetes at baseline achieved normal blood sugar Results were published in the New England Journal of Medicine and presented at the American Diabetes Associations 2026 Scientific Sessions

The primary reason is a process called metabolic adaptation, or adaptive thermogenesis

This evidence suggested that high glucose induces the activation of PSCs and promotes their proliferation, leading to increased ECM secretion