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The labels handle it through the escalation schedule itself: a 2.5 mg starting dosage, increases in 2.5 mg increments after at least four weeks on the current dose, and an explicit direction that treatment response and tolerability be considered when selecting the maintenance dosage

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Smucker JD, Bobst JA, Petersen EB, Nepola JV, Fredericks DC

Degradation and Complex Formation DSIP disappeared rapidly from blood through enzymatic degradation, while complex formation and aggregation may have produced slower-moving immunoreactive material

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