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doi: 10.1002/edm2.v7.1 11 PerkovicVTuttleKRRossingPMahaffeyKWMannJFEBakrisGet al

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In this model, genes associated with the one-carbon metabolic pathways, including the folate and methionine cycles, are up-regulated in the fungal cells upon infection, and are supposed to result in enhanced biosynthesis of nucleotides, NADPH, glutathione and methyl groups

The inflammation is another mechanism triggered by FRD in rat intestine, as suggested by an increment in the intestinal protein expression of nuclear factor (NF)-B and interleukin (IL)-6

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